Effects of Electroacupuncture on IL-1β after Total Cerebral Ischemia-reperfusion in Rats

Objective To observe the effects of electroacupuncture on IL-1β in brain tissue of rats after total cerebral ischemia-reperfusion.Methods Thirty male Wistar rats were randomly divided into the sham operation group,model group and acupuncture group,in each group. In acupuncture group and model group,4-vessel-occlusion method was used to make a rat model of cerebral ischemia reperfusion. Acupuncture group used electroacupuncture on points Quchi and Zusanli,6 hours after reperfusion. The rats of each group were killed and ELISA was used for the measurement of IL-1β in brain tissues.Results IL-1β in brain tissue in model group increased significantly compared with sham operation group and acupuncture group(P0.001). No significant differences were found between sham operation group and acupuncture group (P0.05).Conclusion Acupuncture can lower IL-1β content of brain tissue of rats with brain ischemia/reperfusion injury.