Study on intimal hyperplasia model induced by domestic balloon catheter in rats with aortal lesion and its characters

Objective To investigate the characteristics and feasibilities of intimal hyperplasia model induced by domestic-made 2.0 balloon catheter in place of imported balloon catheter in rats with aortal lesion.Methods The rat model of aortal endothelial denudation was established with domestic balloon catheter;and the intimal hyperplasia after vessel endothelial denudation and the active expression of SMα-actin,PCNA and CollagenⅠ were analyzed with immunohistochemistry and histomophorlogical methods respectively.Results Compared with sham operated group,the intimal hyperplasia in the group redenuded arterial endothelium by domestic balloon catheter was not obvious and the expressions of SMα-actin and PCNA were also not obvious after 7 days;then,hyperplasia began to be observed obviously,and the expression of both SMα-actin and PCNA were obvious very much after 14 days;and the diffuse hyperplasia was progressive but the expression of SMα-actin was still not obvious after 21 days.The difference of CollagenⅠexpression between model group and sham operated group was not statistic significance(P0.05).Conclusions The vessel restenosis is caused after de-endothelialization from 14 to 21 days,in which the hyperplasia is mainly resulted by proliferation of vascular smooth muscle cell,which shows that domestic balloon catheter can be in place of imported 2F Forgarty one.