Comparison of target controlled infusion versus intermittent bolus injection of rocuronium during isoflurane anesthesia

Objective To compare neuromuscular blockade of rocuronium of target controlled infusion based on Szenhradszky pharmacokinetic parameter set with intermittent bolus injection. Methods Thirty patients scheduled for abdominal surgery undergoing general anesthesia were divided into two groups. After loss of consciousness, a target blood concentration of 3 μg/mL rocuronium was administered with a TCI syringe driver based on Szenohradszkay pharmacokinetic parameter set and maintained T 110% throughout surgery in TCI group (n=15). Bolus dose of 0.6 mg/kg rocuronium was injected intravenously for trachea intubation. 0.15 mg/kg rocuronium was given whenever T 1 restore to 25% in control group (n=15). Results Onset time of control group was significantly faster than that of TCI group (P0.01).The rocurionium consumption of TCI group was more than control group significantly (P0.01).There were no significant difference of total dose,recovery time to 75% of T 1,recovery index and recovery time to T 4/T 10.7 between two groups (P0.05). Equal intubation condition and maximum neuromuscular block of T 1 were obtain in two groups. Conclusion Target control infusion of rocuronium can obtained equal neuromuscular blockade comparing with intermittent bolus injection during short surgery, and muscle relaxation is more stably maintained.