Study on resistance to the antibiotics of Escherichia coli producing extended spectrum bata lactamase

Objective: To study the producing ratese of extended-spectrum beta-lactamase (ESBL) and resistance to antibiotics among Escherichia coli(E.coli) islated from clinical infective specimen. To indicate clincal infective specimen. To indicate clincal selecting rationaly usage of drugs. Methods: susceptibility to antibiotics'tests of 120 E.coli strains was measured by K-B paper disk diffusion. ESBL'detection was measured by concentration gradient method of E-test and VITEK microbe auto-analysis instrument respectively. Results: the drug-resistant rates among 120 E.coli strains to Imipenem were lowest with 5%. The drug-resistant rates of E.coli to Cefoperazone Sulbactam、Amikacin and Ceftazidime were, respectively, 5.8%、8.3%、15.8%. The rates of producing ESBL among 120 E.coli strains were 18.33%.Conclusion: ESBL-producing E.coli is resistant to Cephalosporin and Aztreonam, and it's resistance is higher than non-ESBL-producing E.coli markedly.Imipenem and Cefoperazone Sulbactam are the first-choice drugs for treating ESBL-producing E.coli infection.