Research Progress of Terpenoid Indole Alkaloids Metabolism Pathway in Catharanthus Roseus

Catharanthus roseus(L.) can produce more than 130 alkaloids.It is the only natural resource of vinblastine and vincristine and the model plant to investigete the biosynthesis of terpenoid indole alkaloids(TIAs).The MEP pathway is the major way to produce iridoid precursors and the MVA pathway maybe plays a minor role in the alkaloids metabolism.The indole pathway could be up-regulated with methyl jasmonate.It was believed that vindoline could not be yielded in cultured cells.But the recent research revealed that C.roseus C20hi cells could produce vindoline at a minor level.This paper reviews the research progress of TIAs metabolism and some important enzymes in the pathway in C.roseus.