Different Forms of Xiaoyusan External Application in Treating Acute Soft Tissue Injury

Objective:To observe and compare the therapeutic efficacy of different forms of Xiaoyusan in treating acute soft tissue injury in rat models(acute blood stasis type) and to discuss the mechanisms of action.Methods:Sixty rats were made into animal models of blood stasis,and then randomly divided into 4 groups according to different treatments:ointment of Xiaoyusan for group A,liniment for group B;fumigation for group C and no treatment for group D as control.On the 3rd,5th and 10th day,general observation,histological observation,hemorrheology analyses and the test of emodin concentration were made in each group.Results:There was no difference in general observation(P0.05).On day 5,pathological changes in group A was minor than in the other groups(P0.05).On day 3,plasma viscosity,hematocrit,K value of blood sedimentation equation of group A were significantly promoted compared with other groups(P0.01).And the concentration of blood emodin in group A was the highest at each time-point compared with other groups(P0.01).Conclusion:Xiaoyusan ointment has better effects in treating rat models of acute soft tissue injury with acute blood stasis type than liniment or fumigation method.