Effect of compound Danshen drop pills on the treatment of chronic allograft nephropathy

Objective:To investigate the efficacy of compound Danshen drop pills(CDDP) for improving the renal function of patients with chronic allograft nephropathy(CAN).Methods:From January 1,2005 to December 31,2008,66 renal recipients with clinical diagnosis of CAN were enrolled and randomly divided into two groups.Patients in group A(n=34) were treated with immunosuppressive agents and CDDP(27mg/pill,270mg tid).Patients in group B(n=32) were treated with traditional immunosuppressive drugs.SCr,BUN,CCr,and urinary protein in 24 hours(24h Upro) of all patients were measured before and after treatment.Results: After treatment with CDDP for six months,SCr,BUN,CCr and 24h Upro of patients in group A were significantly improved(P0.05).No significant improvement of SCr,CCr and 24h Upro were observed in patients of group B.In group A,renal function was improved in 19 cases,stabilized in 11 cases,and worsened in 4 cases;In group B,renal function improved in 8 cases,stabilized in 12 cases,and worsened in 12 cases(P0.05).Conclusion: CDDP can improve the renal function of the patients with chronic graft nephropathy and retard CAN progression.It offers an alternative option in the treatment of chronic allograft nephropathy.