Characteristics of sedation for upper gastrointestinal endoscopy in younger adults

To investigate the efficacy and risks of using midazolam and propofol for sedation during upper gastrointestinal endoscopic procedures in younger adults. 266 outpatients undergoing gastroscopy. patients were in two groups, A group(younger adults group, n=168, age 18~35 yrs), B group(n=98 age 36~60 yrs ), Each group with midazolam 0.02～0.05 mg/kg (Range1.0～1.5 mg) iv plus propofol 0.5～2.5 mg/kg(Range 40～175 mg) iv before the procedure, Heart rate, blood pressure and SpO2 were obtained for each patient and monitored continuously during and after the procedure. All patients received supplemental oxygen during the procedure. A group received more propofol than B group (P 0.001). All patients showed high satisfaction with sedation and anesthesia. According to staff gastroenterologists, the rating of sedation quality was significantly lower in A group vs B group (89.29% vs 97.96% P 0.05). There were significant change of blood pressure. Clinically important changes in blood pressure were most frequently noted. But the differences between A and B group were not statistically significant. [Conclusions] Under adequate surveillance, midazolam combine propofol can produce safe and effective sedation and anesthesia for gastroscopy. Higher-dose midazolam combine propofol appears more effective in increasing the rating of sedation quality in younger adults.