Preparation and dissolution of bilayer tablets of telmisartan and amlodipine

Objective To prepare bilayer tablets of telmisartan and amlodipine and evaluate its dissolution in vitro.Methods The bilayer tablets were prepared by direct compression and determined using a type of HPLC which could do simultaneously.Dissolution medium contains water,pH 2.0 hydrochloric acid solution,pH 6.8 and pH 7.4 phosphate buffer.Comparison prototype drug with reference drug Twynst through dissolution of paddle.Results The dissolution rate of prototype and reference was similar evaluating by similarity factor method.Conclusion The formulation and processing procedure is suitable for preparing the bilayer tablets.Dissolution rate of bilayer tablets complies with the desired specification.