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Induction of apoptosis in rat thymus by cyclophosphamide

Guan Wang

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Abstract

Objective:To understand the mechanism of immunosuppression of cyclophosphamide. Methods: Investigate if cyclophosphamide produces the immunosuppression by the induction of apoptotic cell death in thymus .Results: 20 and 70 mg/kg cyclophosphamide could induce markedly apoptosis in rat thymus at 12 h after treatment ,the apoptotic cell death took place at 8～24 h and disappeared at 48 h after cyclophosphamide treatment. Conclusion: Cyclophosphamide may causes immunosuppression through the induction of apoposis of thymocyte.

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What this paper is about

Objective:To understand the mechanism of immunosuppression of cyclophosphamide. Methods: Investigate if cyclophosphamide produces the immunosuppression by the induction of apoptotic cell death in thymus .Results: 20 and 70 mg/kg cyclophosphamide could induce markedly apoptosis in rat thymus at 12 h after treatment ,the apoptotic cell death took place at 8～24 h and disappeared at 48 h after cyclophosphamide treatment. Conclusion: Cyclophosphamide may causes immunosuppression through the induction of apoposis of thymocyte.

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Available abstract

Objective:To understand the mechanism of immunosuppression of cyclophosphamide. Methods: Investigate if cyclophosphamide produces the immunosuppression by the induction of apoptotic cell death in thymus .Results: 20 and 70 mg/kg cyclophosphamide could induce markedly apoptosis in rat thymus at 12 h after treatment ,the apoptotic cell death took place at 8～24 h and disappeared at 48 h after cyclophosphamide treatment. Conclusion: Cyclophosphamide may causes immunosuppression through the induction of apoposis of thymocyte.

Key concepts: Cyclophosphamide, Immunosuppression, Apoptosis, Thymocyte, Programmed cell death, Immunology, Apoptotic cell death, Medicine

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