Inhibitory effect of cetylpyridinium chloride on bacteria in vitro

Objective To test the antibacterial effect of cetylpyridinium chloride on four periodontal pathogens. Methods Porphyromonas gingivalis( P. g ATCC33277),Prevotella intermedia( P. i ATCC25611), Actinnomyces viscosus( A. v ATCC19246) and Fusobacterium nucleatum( F. n ATCC10953) were selected. Argrose diffusion test was used and chlorhexidine served as control. The inhibitory effects of cetylpyridinium chloride were examined by testing minimal inhibitory concentration( MIC) and the diameter of inhibitory zone. Results The cetylpyridinium chloride 's inhibitory effect on the four bacterial strains was remarkable,but the difference in the inhibitory effects was not significant between cetylpyridinium chloride and chlorhexidine. Conclusion Cetylpyridinium chloride had same inhibitory effect on the four bacterial strains tested as chlorhexidine.