The Relations of Serum Alphafetoprotein Level and Prognosis in Severe Viral Hepatitis

Objective:The objective of this study was to explore the relations of quantitatively measures of serum alphaferoprotein(AFP)and prognosis in severe viral hepatitis.Methods:The level of blood serum AFP was determined by radioimmunassay in 368 cases with gravis type viral hepatitis,and its change was observed in a dynamic rate.Results:The abnormity rate of AFP was 71.19%,the abnormity rate of AFP in acute severe hepatitis patients was significantly less than that in sub-acute severe hepatitis and chronic severe hepatitis(p0.01),the death rate of patients with AFP20μg/L,AFP20-400μg/L and AFP400μg/L was 79.24%,45.84% and 34.054% respectively,the survival severe hepatitis patients were 170 cases with AFP(282.31±56.32)μg/L in 368 cases,198 cases with AFP(90.42土38.88)μg/L died(p0.01).Conclusion:The blood serum AFP determination in gravis type viral hepatitis can be used as a sensitive index for prognosis.A high level of AFP indicates that hepatitis cells regeneration is active and the prognosis is relatively better.