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2006•Unpublished venueRequires access

The Effect of Damaging Substantia Nigra with 6-OHDA on Sensory Gating of Striatum in Rats

Yang Li-jiang

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Abstract

Objective To observe whether sensory gating (SG) exists in striatum and the influence of 6-hydroxydopamine on sensory gating of striatum in rats. Methods The unilateral substantia nigra compacta (SNc) of rats was damaged by 6-OHDA and the sensory gating ofthe control and PD rats were recorded with a recording electrode in striatum.Results (1)The T/C ratio of striatum in normal female rats(C group, n=22) was (60.19±8.83)%.(2)The T/C ratio in Parkinson's disease model group(group PD, n=19) was (42.34±5.81)%, which decreased compared with C group. There was statistically significant difference between PD group and the C group (P0.05). Conclusions: Sensory gating exists in Striatum and the damaged unilateral subtantia nigra reduces the T/C ratio of ipsilaeral striatum in female rats.

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Objective To observe whether sensory gating (SG) exists in striatum and the influence of 6-hydroxydopamine on sensory gating of striatum in rats. Methods The unilateral substantia nigra compacta (SNc) of rats was damaged by 6-OHDA and the sensory gating ofthe control and PD rats were recorded with a recording electrode in striatum.Results (1)The T/C ratio of striatum in normal female rats(C group, n=22) was (60.19±8.83)%.(2)The T/C ratio in Parkinson's disease model group(group PD, n=19) was (42.34±5.81)%, which decreased compared with C group. There was statistically significant difference between PD group and the C group (P0.05). Conclusions: Sensory gating exists in Striatum and the damaged unilateral subtantia nigra reduces the T/C ratio of ipsilaeral striatum in female rats.

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Available abstract

Objective To observe whether sensory gating (SG) exists in striatum and the influence of 6-hydroxydopamine on sensory gating of striatum in rats. Methods The unilateral substantia nigra compacta (SNc) of rats was damaged by 6-OHDA and the sensory gating ofthe control and PD rats were recorded with a recording electrode in striatum.Results (1)The T/C ratio of striatum in normal female rats(C group, n=22) was (60.19±8.83)%.(2)The T/C ratio in Parkinson's disease model group(group PD, n=19) was (42.34±5.81)%, which decreased compared with C group. There was statistically significant difference between PD group and the C group (P0.05). Conclusions: Sensory gating exists in Striatum and the damaged unilateral subtantia nigra reduces the T/C ratio of ipsilaeral striatum in female rats.

Key concepts: Striatum, Substantia nigra, Pars compacta, Sensory gating, Gating, Internal medicine, Sensory system, Neuroscience

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