Effects of Different Pneumoperitoneum Pressures on Liver Function in Diabetic Patients Undergoing Laparoscopic Cholecystectomy

Objective To investigate the effects of different pneumoperitoneum pressures on hepatic function in diabetic patients undergoing laparoscopic cholecystectomy(LC).Methods Forty diabetic patients treated with LC were divided into two groups: low pressure pneumoperitoneum with a constant intra-abdominal pressure of 1.3 kPa(LP group,n=20) and standard pressure pneumoperitoneum with a constant intra-abdominal pressure of 1.6 kPa(SP group,n=20).Venous blood was collected to determine the liver function before operation and at 1,24 and 72 hours after operation.Results The levels of aminotransferase(ALT),aspartate aminotransferase(AST),total bilirubin(Tbil)and direct bilirubin(DBil)significantly increased at 1 and 24 hours postoperatively,but restored to normal levels at 72 hours postoperatively in both groups(P0.01).Moreover,the increase in these serum indexes in SP group was more obvious than that in LP group(P0.01).Conclusion The LC with carbon dioxide pneumoperitoneum is feasible in diabetic patients,but may result in transient liver function abnormalities,which relate to the levels of carbon dioxide pneumoperitoneum.