Comparison of valuation of thin-layer,liquid-based cytology pap smear test with conventional Papanicolaou smear in screening cervical cancer

[Objective] To evaluate the diagnostic valuation of the thin-layer,liquid-based cytology pap smear test(TCT) with the conventional Papanicolaou smear in screening early stage cervicalcarcinoma and precancerous lesion in order to provide a right diagnosis to the clinical doctors.[Methods] Adult women(n=1685) were enrolled for the cytological examination by the method of the conventional Papanicolaou smear in 50's and the thin-layer,liquid-based cytology pap smear test in 90's.The results were reported according to TBS standard bulit in 2001,and histological examination results were used as gold standard to evaluate the diagnostic value of TCT.We controlled the data by statistics.[Results] The accuracy of detection of the thin-layer,liquid-based cytology pap smear test(TCT) and the conventional Papanicolaou smear compared with histological examination was relatively as follows: low grade squamous inner dermal carcinoma lesion(LSIL) 83.12% and 68.31%,high grade squamous inner dermal carcinoma lesion(HSIL) 91.01% and 61.67%,squamous cell carcinoma(SCC) 100% and 75%.[Conclusion] The sensitivity and specificity of TCT are obviously higher than Papanicolaou smear,so this assay is very significant to screening for early stage cervical cancer and precancerous lesion.