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2008•Chinese Journal of Public Health EngineeringRequires access

Effect of Methylmercury Chloride and Trioxide Arsenic on Apoptosis of K562 Cells

Zhenyu Cui

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Abstract

Objective To study the effect of methylmercury chloride(MMC)or trioxide arsenic(ATO) on the apoptosis of K562 cells.Methods MMC or ATO treated K562 cells in 1.25,2.5,5,10 and 20 μmol/L for 24 h,cell apoptosis rate was detected by the way of FITC-AnnexinⅤ/PI.Results With the dose of MMC increasing,the apoptosis rates of K562 cells increased.The apoptosis rate of cells treated with 5.0 μmol/L MMC or ATO for 24 h were(31.54±6.35)% and(25.37±7.68)%,compared with control group(10.36±3.23)%,there was significant difference(P0.05).Conclusion MMC and ATO can induce apoptosis of K562 cells in dose-dependent manner.

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What this paper is about

Objective To study the effect of methylmercury chloride(MMC)or trioxide arsenic(ATO) on the apoptosis of K562 cells.Methods MMC or ATO treated K562 cells in 1.25,2.5,5,10 and 20 μmol/L for 24 h,cell apoptosis rate was detected by the way of FITC-AnnexinⅤ/PI.Results With the dose of MMC increasing,the apoptosis rates of K562 cells increased.The apoptosis rate of cells treated with 5.0 μmol/L MMC or ATO for 24 h were(31.54±6.35)% and(25.37±7.68)%,compared with control group(10.36±3.23)%,there was significant difference(P0.05).Conclusion MMC and ATO can induce apoptosis of K562 cells in dose-dependent manner.

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Available abstract

Objective To study the effect of methylmercury chloride(MMC)or trioxide arsenic(ATO) on the apoptosis of K562 cells.Methods MMC or ATO treated K562 cells in 1.25,2.5,5,10 and 20 μmol/L for 24 h,cell apoptosis rate was detected by the way of FITC-AnnexinⅤ/PI.Results With the dose of MMC increasing,the apoptosis rates of K562 cells increased.The apoptosis rate of cells treated with 5.0 μmol/L MMC or ATO for 24 h were(31.54±6.35)% and(25.37±7.68)%,compared with control group(10.36±3.23)%,there was significant difference(P0.05).Conclusion MMC and ATO can induce apoptosis of K562 cells in dose-dependent manner.

Key concepts: Arsenic trioxide, Apoptosis, K562 cells, Chemistry, Annexin, Methylmercury, Pi, Molecular biology

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