2008•Journal of Apoplexy and Nervous DiseasesRequires access
The expression of NCAM-140kDa in temporal lobe neocortex of patients with intractable epilepsy:the relation between the plasticity of temporal lobe neocortex and intractable epilepsy
Yan Zeng
Open publisher page 0 citations
Abstract
Objective To investigate the expression of NCAM-140kDa in the temporal lobe neocortex of patients with intractable temporal lobe epilepsy and discuss its roles in the formation of intractable epilepsy. Methods 20 cases of brain tissues of intractable epilepsy and 15 cases of nonepileptic brain tissues were collected. The expression of NCAM-140kDa in the specimens were examined through immunohistochemistry and indirect immunofluorescence. Results The NCAM-140kDa staining intensity of immunohistochemistry in the intractable epileptic temporal lobe tissue and the control were 0.2290±0.0427 and 0.1789±0.0258,respectively(P0.05),and the intensity of immunofluorescence were 28.8345±3.2635 and 20.4513±2.2834,respectively(P0.05). Conclusion The expression of NCAM-140kDa has a significant increase in the intractable epileptic temporal lobe neocortex,suggest it might be involved in the formation of intractable epilepsy,and the changes of plasticity of neurons in temporal lobe is closely related with the formation of intractable epilepsy.