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Screening and identification of mimotopes for lipopolysaccharide conservative epitope from random phage display peptide library

Weiyan Wen, Qiangtao Han, Ning Fu

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Abstract

To screen and identify the mimotopes for lipopolysaccharide (LPS) epitope, a random phage displayed dodecapeptide library was screened with a monoclonal antibody 2B4 specifically against LPS conservative epitope. The results demonstrate that the peptides screened with 2B4 antibody are mimotopes for LPS conservative epitope.

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What this paper is about

To screen and identify the mimotopes for lipopolysaccharide (LPS) epitope, a random phage displayed dodecapeptide library was screened with a monoclonal antibody 2B4 specifically against LPS conservative epitope. The results demonstrate that the peptides screened with 2B4 antibody are mimotopes for LPS conservative epitope.

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Available abstract

To screen and identify the mimotopes for lipopolysaccharide (LPS) epitope, a random phage displayed dodecapeptide library was screened with a monoclonal antibody 2B4 specifically against LPS conservative epitope. The results demonstrate that the peptides screened with 2B4 antibody are mimotopes for LPS conservative epitope.

Key concepts: Mimotope, Epitope, Phage display, Monoclonal antibody, Peptide library, Epitope mapping, Antibody, Lipopolysaccharide

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