Comparison study of mycopholate mofetil and cyclophosphamide on refractory nephropathy syndrome

Objective It is to compare the therapeutic effect,adverse effects and safety between Mycophenolate mofetil(MMF) and Cyclophosphamide(CTX) veins stosatherapy on systemic lupus erythematosus(SLE).Methods 60 patients with systemic lupus erythematosus were randomly divided into two groups.Based on hormone application,30 cases in MMF group were given MMF taken orally and 60 cases in CTX group were given CTX intravenous drip discontinuously.They were followed up for 9 months and linical data were observed.The related indexes and possible concomitant adverse effects were detected.Results After the follow up phase,the total effective rate in MMF group was 86.7%and that in CTX group was 50%.The total effective rate of two groupe was not significant difference,24h urine protein quantitation in MMF group was obviously decreased(P 0.05).Serum albumin was obviousely increased(P 0.05).And there was significantly difference(P 0.05).No case tropped out because of serious adverse effects.The total rate of adverse effects in MMF group was 33.3%.And the total rate of adverse effects in CTX group was 46.7%.Conclusion MMF combined with glucocorticoid on SLE has better curative effect and the tolerance is better,but the long-term curativeeffect needs further observing.