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2003•Unpublished venueRequires access

Expression of Wilms'Tumor Gene in Hematopioetic Mailgnancies

Pengjiang Liu

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Abstract

Objective:To study the expression of wilms'tumor gene(WT1)in hematopioetic malignanˉcies.Methods:Using the method of RT_PCR,the expression of WT1mRNA was detected in158patients with various hematopioetic malignancies and30healthy subjects.Results:The positive expression rate of WT1gene was45.3%(29/64)in patients with acute leukemia(AL).The patients with chronic myeloid leukemia(CML)in chronic and acederative phases did not express WT1gene;but when the CML patients progressed to blastic crisis,all of them did.The positive expression rate of the WT1gene was22.4%(11/49)in patients with mycelodysplastic syndrome(MDS).In patients with lymphona or malignant histocytosis,the positive expression rates of the WT1gene were39.1%(9/23)and41.7%(5/12),respectively.There was no expression of the WT1gene in normal controls.Conclusion:Aberrant overexpression of the WT1gene may contribute to hematopioetic neoplasia.The expression of WT1gene progressively increases as patient's condition worsen.

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What this paper is about

Objective:To study the expression of wilms'tumor gene(WT1)in hematopioetic malignanˉcies.Methods:Using the method of RT_PCR,the expression of WT1mRNA was detected in158patients with various hematopioetic malignancies and30healthy subjects.Results:The positive expression rate of WT1gene was45.3%(29/64)in patients with acute leukemia(AL).The patients with chronic myeloid leukemia(CML)in chronic and acederative phases did not express WT1gene;but when the CML patients progressed to blastic crisis,all of them did.The positive expression rate of the WT1gene was22.4%(11/49)in patients with mycelodysplastic syndrome(MDS).In patients with lymphona or malignant histocytosis,the positive expression rates of the WT1gene were39.1%(9/23)and41.7%(5/12),respectively.There was no expression of the WT1gene in normal controls.Conclusion:Aberrant overexpression of the WT1gene may contribute to hematopioetic neoplasia.The expression of WT1gene progressively increases as patient's condition worsen.

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Available abstract

Objective:To study the expression of wilms'tumor gene(WT1)in hematopioetic malignanˉcies.Methods:Using the method of RT_PCR,the expression of WT1mRNA was detected in158patients with various hematopioetic malignancies and30healthy subjects.Results:The positive expression rate of WT1gene was45.3%(29/64)in patients with acute leukemia(AL).The patients with chronic myeloid leukemia(CML)in chronic and acederative phases did not express WT1gene;but when the CML patients progressed to blastic crisis,all of them did.The positive expression rate of the WT1gene was22.4%(11/49)in patients with mycelodysplastic syndrome(MDS).In patients with lymphona or malignant histocytosis,the positive expression rates of the WT1gene were39.1%(9/23)and41.7%(5/12),respectively.There was no expression of the WT1gene in normal controls.Conclusion:Aberrant overexpression of the WT1gene may contribute to hematopioetic neoplasia.The expression of WT1gene progressively increases as patient's condition worsen.

Key concepts: Wilms' tumor, Myeloid leukemia, Medicine, Gene, Leukemia, Wilms tumour, Cancer research, Internal medicine

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