ScholarLens Back to search
2001•PubMedRequires access

[Therapeutic effect of Astragalus and Angelica on renal injury induced by ischemia/reperfusion in rats].

Sheng Mx, Li Jz, Wang Hy

Open publisher page 9 citations

Abstract

OBJECTIVE: To observe the effect of Astragalus and Angelica on acute renal injury. METHODS: Using the ischemia/reperfusion model established by blocking blood flow through clamping of bilateral renal artery for 45 min, the changes of glomerular filtration rate (GFR), renal plasma flow (RPF), fractional excretion of sodium (FENa), urinary volume (UV) and mean arterial pressure (MAP) as well as the morphological change of kidney before and after ischemia/reperfusion were observed. RESULTS: Astragalus and Angelica could promote recovery of RPF and GFR after ischemia/reperfusion, prevent the oliguria or shorten the oliguria period, reduce the increment of FENa and improve the histomorphological injury of kidney. CONCLUSION: Astragalus and Angelica have certain effect in protecting kidney from acute renal injury.

About this research paper

What this paper is about

OBJECTIVE: To observe the effect of Astragalus and Angelica on acute renal injury. METHODS: Using the ischemia/reperfusion model established by blocking blood flow through clamping of bilateral renal artery for 45 min, the changes of glomerular filtration rate (GFR), renal plasma flow (RPF), fractional excretion of sodium (FENa), urinary volume (UV) and mean arterial pressure (MAP) as well as the morphological change of kidney before and after ischemia/reperfusion were observed. RESULTS: Astragalus and Angelica could promote recovery of RPF and GFR after ischemia/reperfusion, prevent the oliguria or shorten the oliguria period, reduce the increment of FENa and improve the histomorphological injury of kidney. CONCLUSION: Astragalus and Angelica have certain effect in protecting kidney from acute renal injury.

Why it matters

OpenAlex reports 9 citations for this work. Citation counts describe recorded attention and do not establish research quality.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

OBJECTIVE: To observe the effect of Astragalus and Angelica on acute renal injury. METHODS: Using the ischemia/reperfusion model established by blocking blood flow through clamping of bilateral renal artery for 45 min, the changes of glomerular filtration rate (GFR), renal plasma flow (RPF), fractional excretion of sodium (FENa), urinary volume (UV) and mean arterial pressure (MAP) as well as the morphological change of kidney before and after ischemia/reperfusion were observed. RESULTS: Astragalus and Angelica could promote recovery of RPF and GFR after ischemia/reperfusion, prevent the oliguria or shorten the oliguria period, reduce the increment of FENa and improve the histomorphological injury of kidney. CONCLUSION: Astragalus and Angelica have certain effect in protecting kidney from acute renal injury.

Key concepts: Fractional excretion of sodium, Oliguria, Medicine, Renal ischemia, Renal function, Astragalus, Acute kidney injury, Ischemia

Related papers

Related paper 1Related paper 2Related paper 3
Back to paper searchBrowse research topicsOriginal source
[Therapeutic effect of Astragalus and Angelica on renal injury induced by ischemia/reperfusion in rats]. — Research Paper | ScholarLens