Effect of low central venous pressure on blood loss and hepatorenal function during hepatic resection

Objective: To investigate the effects of low central venous pressure(LCVP) on blood loss and hepatorenal function during hepatic resection.Methods: Thirty-six consecutive patients for elective major heptic resections were randomly divided into two groups,normal central venous pressure group(NCVP,n=19) and LCVP group(n=17).The central venous pressure(CVP) of LCVP group patients was maintained less than 5 cmH2O during hepatic parenchymal transection,while the NCVP group with normal CVP(6~12 cmH2O).The volume of blood loss and transfusion rate,changes of hepatorenal function were compared between the two groups. Results: The volume of blood loss and transfusion rate in the LCVP group(515±212)ml were significantly less than that of the NCVP group(714±267) ml,P0.05.There were no marked difference in renal function between two groups,and the AST,ALT during postoperation were elevated obviously in both groups(P0.01,P0.05).But the AST of LCVP group were lower than the NCVP group(P0.05) in the 7th day. Conclusion: LCVP was beneficial for reducing blood loss and blood infusion during hepatic resection,and had less effect on hepatorenal function.