Advantages of establishment of acute myocardial infarction model by ligation of coronary artery in dogs

Objective To explore the advantage of establishment of acute myocardial infarction by ligation of coronary artery in dogs.Methods The left anterior descending branches of 6 hybrid canines were ligated to establish acute myocardial infarction model.The electrocardiogramic monitor recorded the changes of electrocardiogram after ligation of left anterior descending branch(LAD).The enhanced CT scanning was performed one hour after ligation of LAD.Themorphologicalchangesandsites of ischemic myocardium were observed on enhanced CT images,and the CT value of normal myocardium and that of infarction area were measured.Results Ligation of LAD could obstruct blood flow of LAD accurately.ST-T segment elevated at two minutes after obstructing blood flow of LAD.For 6 hybrids,normal myocardium presented homogenized enhancement before ligating of LAD and ischemic areas at anterior wall or apex showed low density at one hour after LAD ligated.Statistically significant differences of the CT values between normal and infarction myocardium at one hour after ligation were found(P0.01).Conclusion Ligation of LAD is a reliable and easily-operated method of establishing acute myocardial infarction model.It can provide a research basis for cardiac infarction.