Comparison of Clinical Features in Ankylosing Spondylitis Patients with HLA-B27 Negative Expression and Positive Expression

Objective To compare the clinical situation of the patients diagnosed as ankylosing spondylitis(AS) with negative expression and positive expression of human leukocyte antigen B27(HLA-B27).Methods Use flow cytometry to measure HLA-B27 among the 301 patients diagnosed as AS in our hospital.And a comparative analysis has been done between the HLA-B27 negative and HLA-B27 positive patients.Results ①The incidence in male was significantly higher than in female in HLA-B27 negative expression group and positive expression group.The average onset age of HLA-B27-negative patients are older than those of the positive ones of the same sex;②The age of the patients with HLA-B27 negative expression was mainly 31～45,and the positive ones 16～30.③The major first symptoms of both the positive and negative patients were axial and peripheral arthritis.The major clinical symptoms include low back pain and hip pain.The rate of systemic symptom such as fever,night sweat and fatigue in negative patients was significant lower than that in the positive group.Conclusion The average age and onset age of HLA-B27-negative patients are older than those of the positive ones of the same sex,and part of HLA-B27 negative patients' condition was relatively mild.The different clinical features of HLA-B27 negative expression and positive expression patients call for due attention in diagonosing suspected AS patients with negative HLA-B27 expression.