Three-year Follow-up Study of Lupus Nephritis Treated with Mycophenolate Mofetil

【Objective】 To investigate the efficacy and safety of mycophenolate mofetil(MMF) in the treatment of lupus nephritis(LN).【Methods】 Nineteen patients(2 male,17 female) with LN,who had failed cyclophosphamide treatment or to withdraw because of adverse reactions,were enrolled in this study.After proven LN by biopsy,all the patients were treated with MMF,and the administration maintained about 36 months.The proteinuria,serum complement and renal function were assessed at 0,3,6,12,24,36 months,while side effects and their time were observed.【Results】The proteinuria decreased at the third month,and there was a significant difference(P0.05) at the sixth month.The level of serum complement increased remarkably after treatment,with a significant difference(P0.05).After treated for 12 months,the total remission rate of patients was 73.7%(14/19).The renal function of 4 cases in 6 patients with renal failure recovered after MMF treatment,one case had no change,one case progressed into uremia.