Effect of blood circulation capsule on the concentration of IL-1β in rat brain tissue with cerebral ischemia

Objective:To observe the contribution of the blood circulation capsule to the concentration of IL-β in rat brain tissue with cerebral ischemia and to explore mechanism of the blood circulation capsule which restraint cascade reaction of cerebral ischemia.Methods: The rats were randomly divided into three groups: control group,cerebral ischemia group and drug group.12 and 24 hours models were made through embolisming middle cerebral artery.The morphologic change of rat brain was detected under the light microscope and IL-β in the rat brain tissue was detected by the method of immunohistochemistry.Results:After the model was made,IL-1β positive cells in periphery brain tissue increased gradually at deferent time in cerebral ischemia drug treated group.But compared with cerebral ischemia group,they were lower.And the diference between the two groups was significantly(P0.05).IL-β in 12 hours drug group and cerebral ischemia group were higher than control groups(P0.05).IL-β in 24 hours drug groups was significant lower than cerebral ischemia group(P0.01).Conclution:Blood circulation capsule can restrant the syhthesis and secretion and has inhibitory effect on the cascade reaction of the cerebral ischemia.