Different dose and effects of dexmedetomidine in preventing shivering after general anesthesia for laparoscopic surgery

Objective The aim of this study was to investigate different dosages and effects of dexmedetomidine for prevention of postanesthetic shivering. Methods One-hundred twenty patients scheduled for laparoscopic surgery were randomly allocated in four groups: before the operation, slowly injected 0.9% normal saline(group S, dexmedetomidine 0.5 μg/kg(group D0.5), dexmedetomidine 0.75 μg/kg(group D0.75),dexmedetomidine 1.0 μg/kg(group D1.0). HR and rectal temperature [C2] were continually monitered during and after operation, time to extubation was measured. Grades of shivering were recorded. Pain evaluation was assessed by a visual analogue scale, sedation was evaluated by Modified Observer′s Assessment of Alertness/Sedation scale.Results The patients in group S showed a significantly higher HR and postoperative incidence of shivering than those in group D0.75 and group D1.0,(P 0.05). but the extubation time in groupd D0.75 and group D1.0 were longer than patients in group S(P 0.05). Conclusion Slowly injected dexmedetomidine 0.75 μg/kg or 1.0 μg /kg can prevent postanesthetic shivering in laparoscopic surgery effectively.