Clinical Observation of Oxaliplatin Combined with Capecitabine for Advanced Gastric Cancer

Objective To investigate the efficacy and toxicity of Oxaliplatin combined with Capecitabine in treating advanced gastric cancer.Methods Oxaliplatin(130 mg/m2 ,intravenous infusion on day 1 for three hours) and Capecitabine(1000 mg/m2 ,per oral,twice daily for 14 days) were administered in a 21 days treatment course.All patients received at least two courses of treatment.Results Twenty-eight patients were enrolled in this study.All patients were included in the efficacy and adverse events analysis.There were no complete responses,twelve partial responses,giving an overall response rate of 42.8%.The major toxicity included myelotoxicity,peripheral neurotoxicity and hand-foot syndrome,all were generally mild.Conclusions Oxaliplatin combined with Capecitabine demonstrates clinical activity and an acceptable safety profile in patients with advanced gastric cancer.Clearly further investigation is warranted as we work.