Expression of CK19,P53,P63,EMA,and P170 protein in papillary thyroid carcinoma

[Objective] To estimate the clinical value of CK19、P53、P63、EMA on distinguishing benign and malignant thyroid disease especially for PTC.To know more about the meaning of P170's expression in PTC.[Methods] By immunohistochemical method called Elivision,CK19、P53、P63、EMA、P170 are examined respectively in 38 PTC patients and in 38 thyroid benign disease patients.[Results] CK19、P53、P63、EMA expression rates in PTC and benign disease of thyroid were 92.1%(35/38) and 2.6%(P0.005);89.5%(34/38) and 18.4%(7/38)(P0.005);23.7%(9/38) and 10.5%(4/38)(P0.1);34.2%(13/38) and 50%(19/38)(P0.1);In 22 cases of the PTC group,the positive rate of P170 is 57.9%.[Conclusions](1) CK19 and P53 are valuable assistant diagnostic points for PTC pathological diagnosis.(2) The positive rate of P170 expression is high in PTC and closely related to CK19.