2001•Europe PMC (PubMed Central)Requires access
The Relation Between TNF Microsatellite Loci Polymorphism and Systemic Lupus Erythematosus in Yunnan People
Zheng Chu, Sun Hao, Yaping Qian, Lei Shi, Yu Jiankun, Chu Jiayou
Open publisher page 0 citations
Abstract
We have investigated TNF microsatellite polymorphism in SLE A total of 97 Chinese Han SLE patients and 79 matched Chinese Han controls were studied in this study, TNF microsatellites a,b,c,d and e were typed using fluorescent labeled automated genescanning and genotyping TNFa1(P =0 0206), c2 (P =0 0000) allele frequencies were significantly increased in the SLE group comparing with controls,and TNF a2 (P=0 0163) c3(P=0 0065),c4(P=0 0012),d6(P =0 0448) allele frequencies were significantly increased in controls Meanwhile,we found some new alleles in Chinese which are different form those in Caucasoids.