ScholarLens Back to search
2007•Journal of Brain and Nervous DiseasesRequires access

Study on expression of PSD-95 in hippocampus of mice with vascular dementia

Kang Jun

Open publisher page 0 citations

Abstract

Objective: To explore the changes of the expression of postsynaptic density 95 (PSD-95) in hippocampus of mice with vascular dementia (VD).Methods: The mice were subjected for ischemia reperfusion repeatly on bilateral common carotid arteries by knots to establish the VD models. The changes of behavior were observed through the step-down avoidance test and the expression of PSD-95 was observed by immunohistochemical method. Results: The abilities of the learning and memory of VD mice was impaired. The immunoreactivity of PSD-95 in hippocampal dentate gyrus(DG) decreased (P0.05). Conclusion: The impairment of the abilities of learning and memory of VD mice might be related with the change of PSD-95 in hippocampus.

About this research paper

What this paper is about

Objective: To explore the changes of the expression of postsynaptic density 95 (PSD-95) in hippocampus of mice with vascular dementia (VD).Methods: The mice were subjected for ischemia reperfusion repeatly on bilateral common carotid arteries by knots to establish the VD models. The changes of behavior were observed through the step-down avoidance test and the expression of PSD-95 was observed by immunohistochemical method. Results: The abilities of the learning and memory of VD mice was impaired. The immunoreactivity of PSD-95 in hippocampal dentate gyrus(DG) decreased (P0.05). Conclusion: The impairment of the abilities of learning and memory of VD mice might be related with the change of PSD-95 in hippocampus.

Why it matters

A significance statement is not available in the OpenAlex record.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

Objective: To explore the changes of the expression of postsynaptic density 95 (PSD-95) in hippocampus of mice with vascular dementia (VD).Methods: The mice were subjected for ischemia reperfusion repeatly on bilateral common carotid arteries by knots to establish the VD models. The changes of behavior were observed through the step-down avoidance test and the expression of PSD-95 was observed by immunohistochemical method. Results: The abilities of the learning and memory of VD mice was impaired. The immunoreactivity of PSD-95 in hippocampal dentate gyrus(DG) decreased (P0.05). Conclusion: The impairment of the abilities of learning and memory of VD mice might be related with the change of PSD-95 in hippocampus.

Key concepts: Hippocampus, Vascular dementia, Dentate gyrus, Hippocampal formation, Immunohistochemistry, Postsynaptic density, Postsynaptic potential, Carotid arteries

Related papers

Related paper 1Related paper 2Related paper 3
Back to paper searchBrowse research topicsOriginal source
Study on expression of PSD-95 in hippocampus of mice with vascular dementia — Research Paper | ScholarLens