Effects of acute hypervolemic hemodilution combined with tranexamic acid on hemodynamics blood gas and electrolytes

Objective To study the effects of acute hypervolemic hemodilution (AHH) combined with tranexamic acid (TA) on hemodynamics, blood gas and electrolytes. Methods Forty patients undergoing intracranial surgery were randomly divided into two groups. By intravenous injection , group A was given AHH plus TA and group B was given AHH alone. MAP、 CVP、 HR、SpO 2 , blood gas and plasma electrolytes were respectively recorded before AHH (T 0 ), at 0 min (T 1 ) and 1 h (T 2 ) after AHH, and at the end of operation (T 3 ). Results At T 1 、 T 2 , CVP of both groups were higher than that at T 0 (P 0.05); There was no significant changes in pH, PaO 2 , PaCO 2 and BE. At T 1 、 T 2 , The concentrations of K + 、 Ca 2 + of both groups were lower than that at T 0 (P 0.05), The concentrations of Na + 、 Cl - of both groups were higher than that at T 0 (P 0.05 or P 0.01, but the concentractions of these ions were still within the normal range at T 3 . Conclusion Injection of AHH with 6% hydroxyethyl starch combined with TA has no adverse effect on hemodynamics and blood gas and minor changes in electrolytes of the patients undergoing intracranial surgery are detected.