Analysis on the Change of T Lymphocyte Subsets and NK Cells in Patients with Systemic Lupus Erythematosus

Objective To investigate the relationship between the peripheral blood lymphocyte subsets,disease activity and renal impairment in patients with systemic lupus erythematosus(SLE).Methods T lymphocyte subsets and NK cells from the peripheral blood of 78 patients who suffered SLE were measured,and then the relationship between disease activity,renal symptoms and the states of cellular immunology were analysed.Results CD-8~+and CD-3~+ cells were significantly decreased in the peripheral blood from those patients with active stage of SLE compared to remission phase,while the CD-4~+ cells and CD-4~+/CD-8~+ ratio did not.And NK cells,but not CD-3~+、CD-8~+ cells or CD-4~+/CD-8~+ ratio in patients with renal impairement were found depress.Conclusions The decrease of CD-3~+ and CD-8~+ cells may correlate to the disease activity of SLE patients,but CD-4~+ and ratio CD-4~+/CD-8~+ can not reflect disease activity.While the reduction of NK cells may have relationship with renal suffering.