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Therapeutic effects of mitomycin-loaded nanoparticles-lipiodol administered via hepatic artery against rabbit hepatoma

LI Xiao-jun

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Abstract

OBJECTIVE: To evalunte the therapeutic effects against rabbit hepatoma with mitomycin-loaded nanoparticles-lipiodol (Lip-NMMC) administered via hepatic artery.METHODS:Lip-NMMC was prepared by the interfacial polymerization method. Normal saline, lipiodol, free mitomycin (MMC, 0.4 mg/kg), mitomycin plus blank nanoparticle (MMC+NP, 0.4 mg/kg), mitomycin-loaded nanoparticles (NMMC, 0.4 mg/kg), and Lip-NMMC were injected respectively via the hepatic artery into six groups of rabbit VX-2 liver tumor models. RESULTS:The survival time was prolonged significantly in animals treated with Lip-NMMC, P0.01. The tumor growth inhibition was more significant, P0.01 and necrosis more extensive in comparison with animals received the others.CONCLUSION:Hepatic arterial infusion of Lip-NMMC is more effective compared with other prepartions.

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OBJECTIVE: To evalunte the therapeutic effects against rabbit hepatoma with mitomycin-loaded nanoparticles-lipiodol (Lip-NMMC) administered via hepatic artery.METHODS:Lip-NMMC was prepared by the interfacial polymerization method. Normal saline, lipiodol, free mitomycin (MMC, 0.4 mg/kg), mitomycin plus blank nanoparticle (MMC+NP, 0.4 mg/kg), mitomycin-loaded nanoparticles (NMMC, 0.4 mg/kg), and Lip-NMMC were injected respectively via the hepatic artery into six groups of rabbit VX-2 liver tumor models. RESULTS:The survival time was prolonged significantly in animals treated with Lip-NMMC, P0.01. The tumor growth inhibition was more significant, P0.01 and necrosis more extensive in comparison with animals received the others.CONCLUSION:Hepatic arterial infusion of Lip-NMMC is more effective compared with other prepartions.

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Available abstract

OBJECTIVE: To evalunte the therapeutic effects against rabbit hepatoma with mitomycin-loaded nanoparticles-lipiodol (Lip-NMMC) administered via hepatic artery.METHODS:Lip-NMMC was prepared by the interfacial polymerization method. Normal saline, lipiodol, free mitomycin (MMC, 0.4 mg/kg), mitomycin plus blank nanoparticle (MMC+NP, 0.4 mg/kg), mitomycin-loaded nanoparticles (NMMC, 0.4 mg/kg), and Lip-NMMC were injected respectively via the hepatic artery into six groups of rabbit VX-2 liver tumor models. RESULTS:The survival time was prolonged significantly in animals treated with Lip-NMMC, P0.01. The tumor growth inhibition was more significant, P0.01 and necrosis more extensive in comparison with animals received the others.CONCLUSION:Hepatic arterial infusion of Lip-NMMC is more effective compared with other prepartions.

Key concepts: Lipiodol, Mitomycin C, Saline, Therapeutic effect, Medicine, Artery, Necrosis, Pharmacology

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Therapeutic effects of mitomycin-loaded nanoparticles-lipiodol administered via hepatic artery against rabbit hepatoma — Research Paper | ScholarLens