2007•Chongqing Yike Daxue xuebaoRequires access
Effect of Nimodipine on the expression of synaptic protein and mRNA in diabetic rat hippocampus
Gao Yuan
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Abstract
Objective:To explore the effect of Nimodipine on synaptophysin in diabetic rat.Methods:38 Wistar rats were divided into the normal control group, diabetic model group, the Nimodipine treatment group randomly. Streptozotocin-diabetic rat model was established. The diabetic rats were treated with Nimodipine for 12 weeks. Then, the learning and memory abilities of rats were tested with the Morris water maze.The mRNA and protein level of synaptophysin in hippocampus were detected by RT-PCR and immunohistochemical method. Results:Compared with diabetic model group, the Nimodipine treatment group showed a significant decrease in the mean time of escape latencies(P0.05)and a increase in percentage of stay time in the the central area and the number of passing the original platform position(P0.05).And the expression of synaptic protein and mRNA in hippocampus were elevated significantly(P0.05).Conclusion:It is concluded that Nimodipine could improve cognitive ability in diabetic rat through increasing the expression of synaptophysin.