Clinical analysis of 60 cases of cervical carcinoma treated with HDR 192 Ir after loading intracavitary irradiation plus external beam radiation therapy

Objective:To study the therapeutic effect and complications of cervical carcinoma treated with HDR 192Ir afterloading intracavitary irradiation plus external beam radiation therapy(EBRT).Methods: From March 2005 to January 2007,60 cervical cancer patients confirmed pathologically were treated with 8MV-X combination of HDR 192Ir afterloading intracavitary brachytherapy plus EBRT.A midplane dose of 25-40Gy to the whole pelvis and additional 20-25 Gy EBRT to the parametrical areas were given.Intracavitary brachytherapy was delivered to a total dose of 36-42 Gv at 6 Gy per fraction,once a week.Results:The rate of CR and PR was 100%.All patients were fo1lowed up over three years.The 3-year survival rates for stage lI and III stage lesions were 88.3% and 82.9%.Immediate radiation rectal reaction and cystitis were 12.4% and 5.2%.Chronic radiation reaction rates were 13.8% and 3.8%,respectively.Conclusion:HDR after loading intracavitary brachytherapy combined with EBRT is efective in treatment of carcinoma of uterine cervix.Meanwhile,the survival rate of patients is higher and the patient tolerated well with few complications.