[Progress of parathyroid hormone and parathyroid hormone-related protein on normal and osteoarthritis cartilages].

OBJECTIVE: To review the progress of mechanism of parathyroid hormone (PTH) and parathyroid hormone-related protein (PTHrP) on normal and osteoarthritis (OA) cartilage and subchondral bones. METHODS: Recent literature about the effects of PTH and PTHrP on normal and OA cartilage was reviewed. RESULTS: PTH and PTHrP can repress the hypertrophic differentiation and apoptosis of chondrocytes and promote their proliferation, which has a protection effect on chondrocytes of OA; osteoblasts from subchondral bone of OA show a decreased reaction to PTH. CONCLUSION: PTH and PTHrP may delay and protect the progression of OA, which involves in regulating cartilage degeneration and subchondral bone remodeling through many kinds of signal pathway.