Significance of GABA_A receptors in the development of some neuropsychiatric diseases

γ-aminobutyric acid(GABA)is an inhibitory neurotransmitter in the central nervous system(CNS),with wide physiological role via GABAA,GABAB and GABAC receptors.GABAA receptor,a dominant type of GABA receptors is comprised of different subunits coming from eight subunit clusters.Whereas its typical molecular structure is a hetero-pentameric complex,being comprised of two α,two β and one γ subunits.And different subunits especially different αsubunit combinations give rise to various physiological and pharmacological effects,which makes GABAA receptor play a great role in the development of some neuropsychiatric diseases such as anxiety,depression,epilepsy and memory disorders etc.Thus GABAA receptor might be an effective target for preventing these neuropsychiatric diseases.