2006•The Journal of Pharmaceutical PracticeRequires access

Inhibitory effects of six flavonoids on collagen synthesis of rat hepatic stellate cells

Qi Li, Pla Nanjing

Abstract

Objective: To study the effects of six flavonoids (fisetin, quercetin, apigenin, phloretin, hesperectin, and chalcone) on collagen synthesis of immortallized rat hepatic stellate cell line HSC-T6 cells. Methods: Collagen synthesis was determined by 3H-proline incorporation. Results:Fisetin, quercetin, apigenin, phloretin, hesperectin, and chalcone (12.5-50μmol/L) concentration-dependently diminished collagen synthesis stimulated by serum, macrophage conditioned medium ( MCM) and transforming growth factorβ1(TGFβ1). Conclusion:The six flavonoids inhibited the collagen synthesis of hepatic stellate cells, which may have potential therapeutic effects against liver fibrosis.

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Key concepts: Hepatic stellate cell, Apigenin, Chemistry, Phloretin, Chalcone, Hepatic fibrosis, Fisetin, Quercetin