Protectine effect of ischemic preconditioning on the small intestine ischemic-reperfusion injury in rat

To investigate the effect on small intestine mediated by the ischemic preconditioning after ischemic-reperfusion injury.SD rats were randomly assigned into the following study groups,S group: sham operation group,n=8;A group: ischemic-reperfusion injury group,n=8;B group: ischemic preconditioning on the rat's small intestine plus ischemic-reperfusion injury group,n=8.When the intestine was reperfused for 1 h,the MDA and MPO of the intestine were determined.The SOD and NO were determined in serum as well.The morphological change of the epithelial basement membrane was oberserved by light microscope.MPO and MDA in A group was significantly higher than those in S and B group.SOD and NO in A group were lower than those in S and B group as well;The mucosal wet weight,villus height and villus area in A group were significantly lower than those in S and B group.The lesion of the morph was milder in B group than that in A group through light microscope.Ischemic preconditioning had an early protective effect on the rat small intentine after ischemic-reperfusion injury.