Efficacy observation of early hyperbaric oxygen on treatment on 35 cases of cerebral diffuse axonal injury

Objective To observe the therapeutic effect of hyperbaric oxygenation(HBO)on cerebral diffuse axonal injury and to analyze its action mechanism.Methods 70 patients with diffuse axonal injury were randomly divided into two groups,HBO treatment group(n=35)and control group(n=35).The therapeutic effects including the average awakening time in awaking patients,the changes in GCS,GOS 6 months after treatment,the ratio of vegetative state and mortality were observed and compared for both groups.Results The average awakening time in awaking patients of HBO treatment group was significantly shorter than that of control group(P0.01).There were significantly differences in GCS scores after 3 treatment courses and GOS scores after 6 months between two groups(P0.01),the ratio of vegetative state and mortality in HBO treatment group were significantly lower than those in control group(P0.05).The total effective rate and healing rate in HBO treatment group were significantly higher than those in control group(P0.01).Conclusion Early HBO treatment for cerebral diffuse axonal injury can shorten patients' coma time,decrease mortality and disabled rate,and promote the recovery of nerves function of patients with cerebral diffuse axonal injury.