The Clinical Effectiveness Of Low Dose Thalidomide Combined With Dexamethasone On Multiple Myeloma

Objective: To observe the effectiveness of low dose thalidomide combined with dexamethasone(LD-TD) on patients with multiple myeloma(MM).Methods: 18 cases with MM were enrolled for studies.Among them,10 case are initial treament and 8 cases are relapsed or/and refractory patients.The initial dosage of thalidomide was100 mg·d-1 with a increasing in 50 mg·d-1 weekly and the maximum dosage was 200 mg·d-1.At the same time,the administerd dosage of dexamethasone was 10 mg·d-1 for 4 days every month.Results: Among the 18 evaluable patients,3 of them achieved complete remission(CR),6 of them achieved partial remission(PR),7 of them showed partial improving and 2 of them had no effects.Side effects could been tolerate.Conclusion: LD-TD might be effective in these patients with relapsed or/and refractory MM,as well as these patients with initial treatment MM.