Combined Effect of Atorvastatin and Probucol on Contrast-induced Acute Kidney Injury

Objective:To observe the effects of different doses of atorvastatin combined with probucol on contrast-induced acute kidney injury (CIAKI)before coronary angiography(CAG) or percutaneous coronary intervention(PCI). Methods: One hundred and forty-nine cases were randomly divided into 3 groups, standard combined treatment group (n = 46, atorvastatin 20 mg/d,1 time/d and probucol 250 mg/d,3 times/d; intensively combined treatment group (n = 47, atorvastatin 40 mg/d,1 time/d,and probucol 250 mg/d,3 times/d, intaking bolus of atorvastatin 40 mg/d,1 time/d and probucol 500 mg 2 hours before intervention; intensive atorvastatin therapy group (n = 56, atorvastatin 40 d,1 time/d, bolus intaking atorvastatin 40 mg 2 hours before procedure. The values of urea nitrogen (BUN), serum creatinine (Scr), and all items rennin were detected before angioplasty and 24 h after angioplasty in patients of 3 groups. The level of glomerular filtration rate (eGFR) was estimated using the MDRD formula. Results: (1) After angioplasty,the levels of Scr and AngⅡ increased significantly,but eGFR decreased significantly in standard combined treatment group(P 0.05). The levels of BUN and AngⅡ decreased remarkably in intensively combined treatment group after angioplasty(P 0.05 or P 0.01), while no significant difference in values of Scr and eGFR. (2)The values of △Scr and △AngⅡ were higher in intensively combined treatment group than those of standard combined treatment group(P 0.05).(3)For the patients of mild to moderate renal function, the values of △Scr and △BUN were significantly higher in intensively combined treatment group than those of the other two groups(P 0.05). Conclusion: The combination of atorvastatin 40 mg and probucol 250 mg or atorvastatin 40 mg before angiography could improve CIAKI. For the patients of mild to moderate renal function, strengthen and combined treatment could improve significantly.