Comparative analysis of anti-Hp effects of sequential therapy and 10 days quadruple therapy

Objective:To compare the Hp eradication effects and patient compliance of sequential therapy and 10 days quadruple therapy and to further explore the mechanism of sequential therapy.Methods:170 patients diagnosed with chronic gastritis and peptic ulcer by endoscopy and tested positive by Hp test(urease test) were randomly divided into A group and B group with 85 patients for each group.A group received the sequential therapy of omeprazole and amoxicillin for the first 5 days and omeprazole,clarithromycin and tinidazole for the rest 5 days.B group received the 10 days quadruple therapy of omeprazole,amoxicillin,clarithromycin and tinidazole.The Hp eradication situation and patient compliance were observed.Results:A group was significantly higher than B group in the Hp eradication rate(P0.05),and patient compliance of A group was higher than that of B group.Conclusion:Under the same treatment course and drug selection,the sequential therapy is significantly better than the 10 days quadruple therapy.