2006•Unpublished venueRequires access
An experimental study of protective effect of Nourishing Yin and Antitoxic Capsule IIon radiation injury by X-ray in rats
Heng-jun Shi
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Abstract
Objective:To observe the radiation injury caused by X-ray and the protective effect of Nourishing yin and Antitoxic Capsule Ⅱ(YCⅡ)in rats. Methods: Thirty adult SD rats were randomly divided into three groups with ten rats for each: the normal group (A), the radiation group (B), the treatment group (C). The rats in group B and C were exposed to whole-body by X-ray radiation at a dose of 6 Gy. And all the rats were treated by intragastric administration. The level of serum malondialdehyde (MDA),activity of serum superoxide dismutase (SOD),activity of serum catalase(CAT)and the total antioxidative capacity (T-AOC) were measured. WBC quantity was counted to evaluate whether the rat model succeeded. The pathological changes of bone marrow of rats were observed by light microscopy . And the spleen and thymus index were counted. Results: YCⅡ delayed significantly the decline of the quantity of RBC and WBC in circulation due to ionizing irradiation (P 0.01), improved the index of thymus and spleen in ionizing irradiation rats(P 0.01) ,increased the activity of superoxide dismutase (SOD) ,catalase(CAT)and the total antioxidative capacity (T-AOC), decreased the level of malodialdehyde (MDA) in the rats's serum . By light microscop a lots of adipocytes were observed , hematopoietic cells swelled and degenerated ,cell nucleus were thick and pyknosised ,cell junction was not clear in group B .And in group C a fewer adipocytes and degenerating cells were observed. Conclusion: YCⅡ has protecting effect on the radiation injury by X-ray in rats.