The effect of growth hormone,glutamine and optimal diet fiber enteral nutrition on intestinal mucosal morphology in patients with short bowel syndrome

Objectives: To investigate the effect of growth hormone(GH),glutamine(Gln) and optimal diet fiber enteral nutrition on the morphology of intestinal mucosa in patients with short bowel syndrome(SBS).Method: Ten patients with SBS received GH(0.05 mg/kg/day),oral Gln(30 g/d),plus optimal diet for 3 weeks.Intestinal mucosal morphology,proliferating and apoptotic status were investigated before and after treatment.Result: All patients completed the treatment.Intestinal mucosal villus height were significantly improved after treatment(P0.05).Intestinal mucosal crypt depth was slightly increased but there was no statistical significance(P0.05).The proliferation levels of the small bowel was increased(P0.05),the apoptotic status was slightly increased but there was no statistical significance(P0.05).Conclusion: Treatment with GH,Gln and optimal diet fiber enteral nutrition has positive effect on intestinal mucosal morphology in patients with short bowel syndrome.