Research progress in peroxisome proliferator-activated receptor γ coactivator-1α

In eukaryotes,cellular and systemic metabolism is primarily controlled by mitochondrial activity.The peroxisome proliferator-activated receptor γ coactivator 1a(PGC-1α) is an important regulator of mitochondrial biogenesis and function.There is currently much interest in PGC-1α,focusing on two important characteristics: tissue-specific expression and induction of a specific signal.PGC-1α is expressed at high levels in tissues where mitochondria are abundant and oxidative metabolism is active.The signal induction activity of PGC-1α is clearly related to the cell's energy metabolism state.For example,cold,fasting and exercise all contribute to a increase in PGC-1α expression.