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2005•Medical Journal of Chinese People HeacthRequires access

A comparative study of paroxetine and imipramine in the treatment of depression

Yulong Liu

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Abstract

Objective:To study the efficacy and side effects of paroxetine in the treatment of depression.Methods:Sixty patients who met with the CCMD-3 criteria of depression were randomly divided into the research group(paroxetine) and control group(Imipramine) for the 6-week treatment.The efficacy was assessed by Hamilton Depression Scale(HAMD) and Hamilton Anxiety Scale(HAMA).The side effects were assessed by Treatment Emergent Symptoms Scale(TESS).Results: Efficacy of paroxetine and imipramine was the similar(P0.05).The improvement rate was 83.33% and 76.67% respectively.Paroxetine had effect on anxiety symptom with less side effects.Conclusions:Paroxetine is an effective and safe antidepressant.

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What this paper is about

Objective:To study the efficacy and side effects of paroxetine in the treatment of depression.Methods:Sixty patients who met with the CCMD-3 criteria of depression were randomly divided into the research group(paroxetine) and control group(Imipramine) for the 6-week treatment.The efficacy was assessed by Hamilton Depression Scale(HAMD) and Hamilton Anxiety Scale(HAMA).The side effects were assessed by Treatment Emergent Symptoms Scale(TESS).Results: Efficacy of paroxetine and imipramine was the similar(P0.05).The improvement rate was 83.33% and 76.67% respectively.Paroxetine had effect on anxiety symptom with less side effects.Conclusions:Paroxetine is an effective and safe antidepressant.

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Available abstract

Objective:To study the efficacy and side effects of paroxetine in the treatment of depression.Methods:Sixty patients who met with the CCMD-3 criteria of depression were randomly divided into the research group(paroxetine) and control group(Imipramine) for the 6-week treatment.The efficacy was assessed by Hamilton Depression Scale(HAMD) and Hamilton Anxiety Scale(HAMA).The side effects were assessed by Treatment Emergent Symptoms Scale(TESS).Results: Efficacy of paroxetine and imipramine was the similar(P0.05).The improvement rate was 83.33% and 76.67% respectively.Paroxetine had effect on anxiety symptom with less side effects.Conclusions:Paroxetine is an effective and safe antidepressant.

Key concepts: Paroxetine, Hamd, Imipramine, Depression (economics), Hamilton depression scale, Antidepressant, Anxiety, Psychology

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