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2008•The Chinese Journal of Modern Applied PharmacyRequires access

Preparation of Eudragit Enteric Capsules

Wenquan Liang

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Abstract

OBJECTIVE To search for alternative material for gelatin,prepare enteronic hard capusles,and evaluate the capsules in pharmaceutical method.METHODS The membranes of Eudragit L100-55 were prepared and investigated,capsules were prepared by a dipping process,in vitro release test was taken and acetaminophen was uesd as the model drug.RESULTS Opitimized formulation was obtained and the capsules prepared met the requirement of Chinese Pharmacopeia to enteric capsules.CONCLUSION Eudragit L100-55 could be a kind of well alternative metiral for gelatin,and the in vitro release test accord with the requirement of enteronic drug delivery.

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OBJECTIVE To search for alternative material for gelatin,prepare enteronic hard capusles,and evaluate the capsules in pharmaceutical method.METHODS The membranes of Eudragit L100-55 were prepared and investigated,capsules were prepared by a dipping process,in vitro release test was taken and acetaminophen was uesd as the model drug.RESULTS Opitimized formulation was obtained and the capsules prepared met the requirement of Chinese Pharmacopeia to enteric capsules.CONCLUSION Eudragit L100-55 could be a kind of well alternative metiral for gelatin,and the in vitro release test accord with the requirement of enteronic drug delivery.

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Available abstract

OBJECTIVE To search for alternative material for gelatin,prepare enteronic hard capusles,and evaluate the capsules in pharmaceutical method.METHODS The membranes of Eudragit L100-55 were prepared and investigated,capsules were prepared by a dipping process,in vitro release test was taken and acetaminophen was uesd as the model drug.RESULTS Opitimized formulation was obtained and the capsules prepared met the requirement of Chinese Pharmacopeia to enteric capsules.CONCLUSION Eudragit L100-55 could be a kind of well alternative metiral for gelatin,and the in vitro release test accord with the requirement of enteronic drug delivery.

Key concepts: Gelatin, Enteric coated, Chromatography, Chemistry, Dosage form, Drug delivery, Pharmacology, Medicine

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