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2008•Chinese Journal of Veterinary DrugRequires access

The Comparison of the Pathogenicity and Immunogenicity of the Cell-adapted Virus and SPF-chicken-passaged Virus of the vvIBDV Strain GX8/99

Zhizhong Cui

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Abstract

The GX8/99,a strain of very virulent Infectious Bursal Disease Virus(vvIBDV),has been developed in CEF cell for 22 generations,and has been attenuated after adapting to the CEF cell.The mortality of the 4-week-age SPF chicken has decreased from 85%～90% to 0～5%.And when the cell-cloned virus,GX-2B20、GX-4B20、GX-5B20,were returned to SPF-chicken,the pathogenicity did not increased,the mortality was also 0～5%.In order to research the immunogenicity of the backpassaged virus,we immuned the 2-week-age SPF chicken with GX-2B23、GX-4B23,and infected the vvIBDV GX8/99 after 3 weeks.The results show that both of them could make the bursal atrophie and decrease the antibody degree of the NDV and AIV(H9-,H5-) vaccine significantly.But they both have very good immunogenicity,the protective rate was 100%.

About this research paper

What this paper is about

The GX8/99,a strain of very virulent Infectious Bursal Disease Virus(vvIBDV),has been developed in CEF cell for 22 generations,and has been attenuated after adapting to the CEF cell.The mortality of the 4-week-age SPF chicken has decreased from 85%～90% to 0～5%.And when the cell-cloned virus,GX-2B20、GX-4B20、GX-5B20,were returned to SPF-chicken,the pathogenicity did not increased,the mortality was also 0～5%.In order to research the immunogenicity of the backpassaged virus,we immuned the 2-week-age SPF chicken with GX-2B23、GX-4B23,and infected the vvIBDV GX8/99 after 3 weeks.The results show that both of them could make the bursal atrophie and decrease the antibody degree of the NDV and AIV(H9-,H5-) vaccine significantly.But they both have very good immunogenicity,the protective rate was 100%.

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Available abstract

The GX8/99,a strain of very virulent Infectious Bursal Disease Virus(vvIBDV),has been developed in CEF cell for 22 generations,and has been attenuated after adapting to the CEF cell.The mortality of the 4-week-age SPF chicken has decreased from 85%～90% to 0～5%.And when the cell-cloned virus,GX-2B20、GX-4B20、GX-5B20,were returned to SPF-chicken,the pathogenicity did not increased,the mortality was also 0～5%.In order to research the immunogenicity of the backpassaged virus,we immuned the 2-week-age SPF chicken with GX-2B23、GX-4B23,and infected the vvIBDV GX8/99 after 3 weeks.The results show that both of them could make the bursal atrophie and decrease the antibody degree of the NDV and AIV(H9-,H5-) vaccine significantly.But they both have very good immunogenicity,the protective rate was 100%.

Key concepts: Immunogenicity, Infectious bursal disease, Virology, Virus, Virulence, Biology, Antibody, Pathogenicity

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